Psychometrics and strategy for clinical outcome assessments

SeeingTheta works with small biotechs, CROs and large pharma companies. We help you generate the best evidence for your clinical outcome assessments, and plan the endpoints that use it.

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Our services

We work across two practices, Measurement Science and Strategic Consulting. Most projects draw on both, and the work moves between them as a project develops.

Measurement ScienceStrategic ConsultingBoth

A loop of four stages. Choosing a COA: measure landscape review, goal-led endpoint selection, psychometric evaluation. Evidence generation: psychometric analysis, stand-alone study design. Reporting: psychometric results report, COA dossier. Regulatory strategy: regulatory meeting preparation, rapid decision analysis, strategy workshops and reviews. It leads back to choosing a COA.

Measurement Science

Psychometrics and measurement science

We do the quantitative work behind your COA. That covers validation, meaningful change and how the results are reported to regulators.

Assess→Plan→Enact
  • Psychometric analysisRegulators want proof that your COA measures what it claims. We produce that evidence and write it up for submission.
  • Meaningful change derivationKnow which score change matters to patients, and use it as the responder threshold in your efficacy analysis.
  • Digital health technologyA DHT that fits your trial, with the evidence to back it up.
  • TrainingBring your internal team up to speed with entry, intermediate and advanced courses in psychometrics and digital health technology.
All Measurement Science services

Strategic Consulting

SeeingTheta Strategic Consulting

Launching 8 November 2026

Strategy for COA programmes, built on Rumelt's kernel. We start by diagnosing the challenge, then build the course of action that answers it.

Diagnosis→Guiding policy→Coherent actions
  • Endpoint strategy and regulatory positioningGo into regulatory meetings with endpoints you can defend. We prepare the briefing documents and likely questions with you.
  • COA strategy and courses of actionWhich measure, and what then? We review the literature and your evidence, help you choose or build the measure, and agree the next steps.
  • Goal-led endpoint selectionEndpoints chosen for what your trial needs to show, with a strategy to reach them.
  • Strategy workshops and reviewsAn outside review of your current COA strategy, or a working session to build one.
All Strategic Consulting services

Prefer inspiration to strategy? Inspiration on Demand has a button for that.

How much change matters to a patient?

Regulators ask this of every COA-based endpoint. We derive within-patient thresholds with anchor-based and longitudinal latent methods, and we publish the methods with colleagues so others can use them.

Get the R package on CRAN to put the methods into action.

Meaningful change resources

MiCT, an R package on CRAN

Based on our collaborative publications on meaningful change.

install.packages("MiCT")

Resource spotlight

Anchors sort patients into change groupsConstructlinkageMeaningfulnessDiscrimination

Is your anchor doing its job?

Our framework for showing that an anchor measure sorts patients into meaningful change groups. Published open access in 2026, with tools you can use on your next study.

PaperEvidence recordWorked exampleISOQOL 2026 talk

See the framework and tools

See all resources

Two minutes from ISOQOL 2026

In Prague we gave talks, showed posters and launched The Psychometrician's Handbook. Our film won the first ISOQOL Statistics Special Interest Group Data Visualisation Challenge.

The people we loseFirst place, ISOQOL Statistics SIG Data Visualisation Challenge 2026. Watch the film

See the talks and posters Discuss on LinkedIn

Meet the team

Full bios →
Piper Fromy
Piper FromyFounder and President
Anna Krasnow
Anna KrasnowCo-founder and Managing Director, SeeingTheta Strategic Consulting
Marie-Jeanne Holveck
Marie-Jeanne HolveckStatistics and Programming
Maryam Bayram
Maryam BayramPsychometrics and Methodology
Elisa Berger
Elisa BergerStatistics and Programming
Kacylia Pistoia
Kacylia PistoiaCOA Science and Methodology
Nikola Markiewicz
Nikola MarkiewiczPsychometrics and Methodology

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Still from the ISOQOL 2026 round-up video: the title card over a street in Prague Piper Fromy · 24 October 2026 · Video ISOQOL 2026 in Prague, in two minutes Thoughts on the way home: the booth, the talks, the long conversations about hard measurement problems, and the launch of The Psychometrician’s Handbook with the colleagues who wrote it. Next stop, Vienna. Watch on LinkedIn →
Piper Fromy · 3 November 2026

Is your team a leader in the field, or just happy following others? Three of the five seats on the BF-PROM brain fog measure are taken. If you don’t make the choice soon, your competitors will make it for you.

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Piper Fromy · 30 October 2026

After two years of grumbling about the AI hype train, I’m presenting a poster about a large language model. It re-codes trial interviews for new questions. The model does the slow, repetitive first pass, and the researcher keeps the judgement calls.

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Piper Fromy · 28 October 2026

After Prague, we’re off to Vienna. Find us at ISPOR Europe, 8 to 11 November, at booth 1604, with two posters, a workshop, copies of the Handbook, and Iris. Bring your hardest measurement question.

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